More evidence of ancient DNA in modern humans.

From: Glenn Morton (glenn.morton@btinternet.com)
Date: Mon Sep 09 2002 - 01:00:08 EDT

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    The melanocortin region of the modern human genome has was studied by Makova
    et al and shown to contain evidence that mankind has been an interbreeding
    group for a very long time. Below is the table showing the 95% confidence
    intervals for how long it would take modern diversity to arise (known as the
    time to the most recent ancestor-TMRCA)
    The age (T, 10^3 yr) of the MRCA of human sequences

    Sequences Ne Tmode Tmean 95% interval
    All samples
                10,000 1,520 1,577 8562,392
                12,000 1,325 1,412 7392,227
                15,000 1,104 1,220 6122,004
    Africans
                6,000 1,536 1,573 9462,218
                8,000 1,382 1,473 8382,182
                10,000 1,288 1,365 7442,088
    Non-Africans
                6,000 768 811 3891,344
                7,000 694 766 3581,299
                8,000 646 728 3391,248

    The average mutation rate (2.16 x 10^4/sequence/genera- All sequences
    tion) was used.
    Kateryna D. Makova, Michele Ramsay, Tefor Jenkins and Wen-Hsiung Li, Human
    DNA Sequence Variation in a 6.6-kb Region Containing the Melanocortin 1
    Receptor Promoter, Genetics 158(2001, 1253-1268, p. 1263

    All examples lead to the probability that our common human ancestor is much
    older than mitochondrial Eve and to the conclusion that our common ancestor
    was not anatomically modern.

    glenn

    see http://www.glenn.morton.btinternet.co.uk/dmd.htm
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