Another interesting article in the Jan-Feb issue is "The molecular anatomy
of an ancient adaptive event." This is an interesting read for anyone who
is intersted in the issues and methods surrounding protein reconstruction
in an evolutionary context. The finding that a replacement of a single
amino acid chages a lactate dehydrogenase into a malate dehydrogenase is
particularly interesting and there is a case made for a sort of "punctuated
equilibrium" for the evolution of enzyme functions.